Pulled over for speeding, Dareus was charged with felony possession of drugs -- "synthetic marijuana" or "bath salts".
Many of these designer drugs are actually legal, because as soon as one ingredient is banned, the creators change the chemical formula.
Police said they also found drug paraphernalia in Dareus' car
A jailer in Cleburne County in Heflin who would not give her name says Dareus was arrested Monday night by a state trooper and was released from the jail within an hour.
Dareus was selected third overall in the 2011 draft and is in his fourth season with the Bills. The 24-year-old played for Alabama.
Last season he had 7.5 sacks and 71 tackles.