The raids occurred last Friday, Saturday, and Monday.
In addition to the 63 arrests, Buffalo Mayor Byron Brown says police seized eight guns, crack cocaine, heroine, marijuana, assorted pills, and more than $3,000 in cash.
"We made a commitment that we would intensify our focus on drugs, guns, and quality of life crime," Brown said during a Thursday afternoon news conference at Buffalo Police headquarters.
And he offered this message to those considering any criminal activity in Buffalo.
"Don't feel comfortable. You are not going to get away with it," he said.
Police commissioner Daniel Derenda says the police got tips from citizens through the department's confidential tip line, the 311 line, and 911.
"This is the continuation of the mayor's zero-tolerance crime policy ... ultimately helps rid the neighborhoods of illegal drugs," Derenda said.
Buffalo Police say they got help from the Drug Enforcement Administration (DEA), the Erie County Sheriff's Department, and SWAT Teams from Amherst, Hamburg, Lancaster, Niagara County, State Police, and the town of Tonawanda.
The city of Buffalo is able to conduct these large-scale operations with funding from the New York State Division of Criminal Justice Services Operation Impact.