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"From my point of view ... I'm giving myself a 70-75 percent chance to play. You know, I just feel ... it's a game that we need to go out and play well .. and I need to be out there, I think, to play, so I think I'll have that opportunity to get out there, and if I keep working and those guys keep doing the tremedous job they're doing, I'll get out there," Jackson said.
Jackson expects to practice on Wednesday for the first time since getting hurt in a season-opening loss at the New York Jets two weeks ago.
Coach Chan Gailey concurred with Jackson's prognosis after the player had a workout earlier in the day that went "extremely well." Gailey said he's "very optimistic" Jackson will play Sunday.
Jackson's return has the potential to provide a big boost to Buffalo's running attack after Spiller was hurt in a 24-14 win at Cleveland.
Head coach Chan Gailey also says C-J Spiller's left shoulder injury wasn't as bad as first thought, but he probably won't see action on Sunday.
"Maybe not as bad as originally thought ... Not going to completely rule him out this week, but it's more of a chance that he won't [play] than he will," Gailey said.
Gailey says Spiller could return for the game against the 49ers the following week.