The Bills will take the field at 5-10, having lost four of their last five. The Jets are just a game better at 6-9, having lost two straight.
Bills safety George Wilson says he knows both teams are playing for pride, so that will be his motivation.
"You're only as good as your last performance. You want to be able to perform at your best. You don't when that next opportunity's going to be. Next season is a long way away, so you obviously want to try to play well, and, like I say, end the season on a positive note," Wilson said.
And he says the Bills haven't forgotten the 48-28 defeat at MetLife Stadium in Week 1.
The Jets quarterback issue continues making headlines heading into the final regular season game.
Greg McElroy has a concussion and will be replaced by Mark Sanchez.
Head coach Rex Ryan says he chose to start Sanchez over Tim Tebow because the team has just two practices and a walkthrough to prepare before the game and he feels "more comfortable" with Sanchez.
Sanchez was benched after turning the ball over five times at Tennessee on Dec. 17.
It's a 1 p.m. kickoff at Ralph Wilson Stadium, and blacked out on local TV, so full coverage is available on sister-station WGR 550.