The National Weather Service has a Winter Storm Warning posted for all of Western New York through Wednesday evening.
Snow totals could be in the 6 to 12 inch range. The snow is expected to last later intot he day Wednesday across the northern portion of the region.
Here is a state by state look at the latest winter storm:
Officials at the University of Arkansas at Fayetteville canceled classes Tuesday, citing icy roads. It was one of several college campuses that closed for at least part of the day.
Northwest Arkansas Community College in Bentonville, Arkansas State University in Jonesboro, the University of Arkansas at Little Rock, the University of Central Arkansas at Conway and the University of Arkansas at Fort Smith also gave students the day off.
Connecticut's governor and legislative leaders delayed the start of the annual session of the General Assembly because of the winter weather.
Gov. Dannel P. Malloy said Tuesday that legislative leaders agreed to delay the planned Wednesday opening to Thursday. The joint session will begin at noon Thursday when Malloy delivers his State of the State Address.
Authorities were suspecting that poor road conditions may have contributed to a vehicle collision in Des Moines that killed one person.
Police say the crash was reported at 7:50 a.m. Tuesday on Highway 5 on the city's south side. A pickup truck was traveling westbound when it began sliding sideways and crossed the median. It then struck another vehicle. The driver of the second vehicle was pronounced dead on the scene. The pickup driver was brought in for questioning.
Schools dismissed early across Indiana ahead of a winter storm forecast to bring as much as 10 inches of snow to the northern half of the state and icing in the south.
Indiana University-Purdue University Indianapolis closed Tuesday at 2 p.m. and wasn't due to reopen until 5 p.m. Wednesday. IU Southeast in New Albany also closed at 2 p.m., and several Ivy Tech Community College campuses announced early closings.
With as much as a foot expected in the state capital of Topeka, lawmakers postponed legislative work and state departments urged workers to stay home. Classes were canceled throughout the state, but the heaviest snowfalls were anticipated in a wide swath from Hutchinson in central Kansas to Topeka in northeast Kansas. By early morning, 3 to 4 inches were already on the ground there.
Gov. Sam Brownback hopped aboard a Kansas Department of Transportation snowplow Tuesday afternoon to observe snow removal on Interstate 70 west of Topeka.
Frozen precipitation prompted early shutdowns by businesses around Kentucky.
Kentucky's largest school system, Jefferson County Public Schools, along with Hancock County Schools near Owensboro ordered students dismissed two hours early. Fort Knox schools and the military installation planned to open two hours late on Wednesday.
Although up to 6 inches were possible in parts of the state, the National Weather Service says Michigan was likely to avoid the worst of the storm. It could create problems for motorists Wednesday morning, though, with southeast Michigan - including Detroit - getting as much as 3 to 5 inches of accumulation.
Kansas City International Airport canceled nearly 50 departing and 40 arriving flights as much of the northern part of Missouri braced for 8 to 11 inches of snow.
The University of Missouri-Columbia was among the schools that closed, calling off classes a day before Tuesday's snowfall arrived. And Missouri education officials postponed a St. Louis public hearing to get public input on proposals to improve unaccredited school districts.
A truck carrying ethanol slid off Interstate 29 in St. Joseph about 4 a.m. Tuesday, prompting the closure of both southbound lanes for nearly three hours. The driver was not injured.
Blowing snow may have been a factor in a fatal crash in eastern Nebraska involving a farm tractor and a pickup truck, authorities said.
The Saunders County Sheriff's Office said 36-year-old Arlin Kasuske, of Ashland, was driving a pickup Tuesday afternoon near a county road when a tractor in the other lane attempted to make a left turn into a farm driveway.
The tractor's front-end loader collided with the side of Kasuske's pickup. He was pronounced dead at the scene.
The driver of the tractor was not injured.
Gov. Maggie Hassan warned New Hampshire residents to limit their travel during the upcoming winter storm.
She said state government agencies will liberally allow leave for employees who cannot safely travel to work on Wednesday.
Ahead of the storm, Hassan postponed Wednesday's scheduled State of the State address and the University of New Hampshire in Durham cancelled classes on Wednesday.
Dozens of schools delayed opening Tuesday as New Jersey dug out from the storm, which dumped more than 9 inches of snow on parts of the state. A winter storm warning was in effect for the state's northern counties until 9 a.m. Wednesday.
Forecasters say Sussex, Warren and Morris counties could receive 6 to 10 inches of snow and up to a tenth of an inch of ice before the precipitation changes over to freezing rain and sleet.
A record-breaking winter dry spell came to an abrupt end in Albuquerque, which saw around 3 inches of snow. That ended the longest period between December and February without any precipitation for the city.
Nearly 4 inches of snow also were recorded in Sana Fe, prompting school officials to cancel classes.
The Department of Transportation says Interstate 25 between Rowe and Raton is snow-packed and icy, and U.S. 64 is snow-packed and icy for about 45 miles east of I-25 and about 70 miles west of I-25.
A utility was warning New Yorkers about possible power outages due to the mix of snow and freezing rain.
Con Edison noted that snow and ice can bring trees and limbs down onto power lines, causing outages.
The National Weather Service has issued a winter storm warning that starts overnight and continues until 6 p.m. Wednesday. New York City was expected to get 4 to 8 inches of snow, plus about one-tenth of an inch of ice.
Ohioans were bracing for a messy rush hour on Wednesday morning, with another 6 to 10 inches of snow expected on the ground overnight.
Southeastern Ohio, which got the brunt of a snowstorm Monday, could escape the worst this time, getting its precipitation in the form of freezing rain and sleet.
The storms are causing a shortage of road salt in some Ohio counties. Geauga County, in northeast Ohio, will combat the coming storm with cinders while it awaits another shipment of salt.
In Columbus, the city's "snow warriors" were treating 300 miles of roadway with a brine solution to help keep snow and ice from bonding to the pavement.
The winter storm that dumped several inches of snow and sleet throughout a huge swath of Oklahoma Tuesday snarled some traffic and closed schools yet again.
But the moisture from the snowfall proved beneficial for one group of Oklahomans - the farmers and ranchers who have suffered through countless drought patterns, parched land and withered crops.
Forecasters say some areas of northern Oklahoma could see up to 10 inches of snow as the storm pummels the state.
State officials planned to gather at the headquarters of the Pennsylvania Emergency Management Agency overnight, starting Tuesday evening with representatives from PennDOT, the State Police, the Pennsylvania Turnpike and the National Guard.
Shortly before midnight they will be joined by the Red Cross and a host of other state agencies, said PEMA spokesman Cory Angell.
The storm was expected to start rolling into the western areas of the state shortly after dark and reach the Harrisburg area around 10 p.m. Significant accumulations - perhaps a half-inch of ice in some areas - were expected to be on the ground by the Wednesday morning commute.
Rhode Island was preparing for another winter storm that's expected to bring several inches of snow and has already forced the pre-emptive closure of some schools.
The National Weather Service has issued a Winter Storm Warning across the state. It forecasts 8 to 12 inches of snow in Providence and Kent counties, and 4 to 8 inches of snow along the coast. The storm is expected to start overnight, creating a difficult commute Wednesday morning, then last into the afternoon.
Schools in some communities have been called off for Wednesday, but the governor's office said state offices will remain open
Although Central Texas enjoyed clear skies with temperatures in the upper 50s, inclement weather was hampering commuters in North Texas south to the Houston area.
At least an inch of snow fell Tuesday on Amarillo with forecasters calling for up to five inches in some areas. A hazardous weather advisory was in effect until noon for much of the Panhandle, with icy conditions reported south in the Lubbock area.
The winter storm heading to New England was expected to dump 6 to 12 inches in parts of Vermont, which has missed out on some of the Northeast's recent snowstorms.
Snow will start falling early Wednesday morning with the heaviest snowfall through midday.
The National Weather Service has issued a winter storm with forecasts for 4 to 8 inches in northern Vermont, including Burlington, and 6 to 12 inches in central and southern parts of the state. An inch of snow an hour is expected during the middle of the day.
The weather service says the storm could cause difficult driving conditions and reduced visibility.
A flood watch was in effect for at least 38 counties in West Virginia. The National Weather Service says an approaching storm is capable of producing an inch or more of rain on already saturated ground Tuesday night through Wednesday afternoon.
And a storm watch for freezing rain has been issued in the Eastern Panhandle and surrounding counties. The weather service says accumulations of a quarter-inch or more of ice is possible.
Chillier than normal temperatures are expected to continue this week across Wisconsin, with snow expected in the southeastern part of the state.
The National Weather Service says snow is expected to begin falling Tuesday night into Wednesday morning in Milwaukee, Racine and Kenosha counties. Those areas could see 3 to 5 inches, while areas further north could see lesser amounts.